I’m observing same problem on macOS 12.5 and intel iCore5 - very slow gui response (30 sec on home icon). Seems to me problem is with ZeroConf. To fix it, go to config file, in my case it is:
~/.config/org.qgroundcontrol/QGroundControl\ Daily.ini
And add next section:
[LinkManager]
autoConnectZeroConf=false