PX4&ESC Protocol Issue

Hi, I’m working on qav250 with pixhawk4-mini.
Right now I’m having Emax bullet 35A ESCs which follows multishot & Oneshot protocol.

What is happening with my quad is -

  1. it flies for 5-10 seconds and lost the throttle
  2. 2&4 motors did not produce thrust of same amount after flying for 5-10seconds.

Is is due to protocol because I’m unable to see whether it is protocol problem or something else ?
I think px4 follow pwm and dshot only !!