Thank Murray_Louw,
This helps a lot. I have the same issue. I connected via usb the Pixhawk 4 Mini one moment was fine, a moment later it was not.
APM: Preflight Fail: Baro Sensor #0 missing
Being my project close to deadline, I was just going to buy another one (while waiting for Holybro feedback).
Not sure now, maybe going for the external barometer of for Pixhawk 4 (hopefully it does not have the same issue).
Many thanks,
Mario