Belated response but I’ll do my best to address these concerns as I have spent the last month building/playing with my x650 using ardupilot (yes I know this is a PX4 forum but there seems to be a lack of response from that standpoint)
1- There are a few videos on YouTube featuring this drone flying and it is available as a kit, so I’m not sure what you mean by testing? Battery life, thrust, ESC temp, etc? If you reply I can make a video on your specific concern
2- you can use suggested tuning parameters in Ardupilot. Simply type in the prop size (15.5”) and the battery (6s 8000mah recommended) and it will give you a base tune that flies very well. You will want to do the gyro notch filter tuning and autotune PIDs to get the best longevity/performance. But a base tune and mandatory hardware setup (frame type, accelerometer, compass, radio, ESC, battery monitor) will get you in the air flying waypoint missions
3- pixhawk should be flashed with latest arducopter firmware, and yes PID tuning is recommended so your ESCs run at optimal temps. They are tucked within the prop arms with no airflow so you need to prevent overheating, which is a risk if the motors are working harder than they should be
4- you simply calibrate the ESC’s using ardupilot, it’s one of the main setup steps. Make sure you use dshot600 and setup the ESC telemetry so you can set up harmonic notch filters (my x650’s base rotor noise frequency was around 65hz and the upward harmonics of that frequency for your reference, I imagine your frame will also have a notch filter in that frequency)
5- not sure what you mean, ESC calibration is done through ardupilot by removing props and pressing a button, motor calibration is not really a thing other than setting motor arm speed and minimum speed. You could use AM32 configurator or BLHELI for more ESC tuning options, depending on which your ESCs are flashed with
6- this is a CHINESE drone frame, expect minimal customer support. Replacement parts are available through their website, although a few (like the carbon prop arms) are out of stock