Problem in connection with QGC - Access port cannot create

Hi,

I tried to connect the flytpod(PX4) with QGC using TTL-USB device. I am getting error message (image attached). Do we need to configure before we interface the flytpod with QGC. I am getting similar error, when i tried to connect the QGC through TCP.

What could be the issue??

Thank you
Arun