Hi @Mitch ,
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Can you try with a USBtoTTL adapter?
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Did you compile the agent from source?
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Can you also check the serial link, running for example a mavlink console on it? (disable uxrce_dds_client, re-enable MAVLINK on telem2)
As suggested on Discord, it could be that the serial port on the jetson is not “free”. If so, then with the USBtoTTL adapter it should work, while MAVLINK on the serial port should not.