EKF2 Status Invalid

I’ve 2 different Pixhawk 2.4.8 with corresponding uBlox M8N and I’m trying to build a Quadcopter.
I’ve uploaded PX4 1.10.1 and done the calibrations without problem.
When I set Position mode, I get a REJECT POSITION CONTROL error. GPS status is ok (3DFix with 12 satelites).
If I issue ekf2 status, I can see both local and global positions as invalid.

Same problem on both boards/GPS.

Any ideas? How do I troubleshoot it?