Unable to disable Safety Switch Pixhawk 4 gps

When I arm the drone from the RC remote the drone arms straight away but the motors do not rotate.
So I was trying ESCs callibration.
When I try to calibrate my ESCs from Qgroundcontrol . I get the error Callibration Failed Unable to disable safety switch.
I am not able to understand the cause of the issue. I have pixhawk 4 GPS and FMUK66 .

When I connected the battery and the FMU and GPS module boots up . I hear 5 consecutive buzzes from the GPS module. Do these buzzes indicate some error?

I am very new to px4 would like your help.

Thank You

you can change CBRK_IO_SAFETY parameter to 22027 and reboot your autopilot.
Good luck