Airframe multicopter new rotor configuration

Hi everybody,

Is it possible to change the geometric disposition of the rotors of an already built multicopter airframe configuration (like the Octorotor taken from the website Airframes Reference | PX4 User Guide)?
Will the PX4 control change dramatically, or will it be easy to handle?

My idea is to dispose the rotors in two rows (left and right of the main body), instead of a circunference shape.

Thank you in advance