Gamepad / Joy stick Vs Radio

Hi All, I am just starting with px4, have built several vehicles and I am about to connect my pixhawks. I will be flying mostly Fly by Wire or completely automatic missions.
Is there a serious disadvantage in using a game pad (QGC is running under windows 10 or Android) over a normal radio? I am not concerned with very fast changes, mainly with manual landing)

Manual landing is actually a quite challenge procedure, if you are not flying a toy.